De Novo Protein Design
De novo approach, also known as the inverse protein folding problem, involves designing proteins from scratch. De novo design has proven a powerful method for understanding protein folding and function, and for mimicking or even bettering the properties of natural proteins. De novo protein design mainly involves the generation of target backbone, the design of sequences whose lowest energy states are the target backbones, and the optimization followed by computational and experimental validation of selected sequence-structure pair.
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https://www.biosynsis.com/de-n....ovo-protein-design.h