The New Dietary Ingredient (NDI) Notification is a process required by the U.S. FDA for any dietary supplement that contains ingredients not sold in the U.S. before October 15, 1994. If you want to create a new vitamin or supplement to promote health, you must inform the FDA about the new ingredients. This notification includes information about the ingredients, the product, how it should be used, and evidence supporting its safety. Following this process is critical to ensuring consumer safety and complying with FDA regulations.